Impact of the <Emphasis Type="Italic">rpoS</Emphasis> genotype for acid resistance patterns of pathogenic and probiotic <Emphasis Type="Italic">Escherichia coli</Emphasis> |
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| Authors: | Sina M Coldewey Maike Hartmann Dorothea S Schmidt Uta Engelking Sya N Ukena Florian Gunzer |
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| Institution: | 1.Institute for Medical Microbiology and Hospital Epidemiology,Hannover Medical School,Hannover,Germany;2.Department of Anesthesiology,Hannover Medical School,Hannover,Germany;3.Department of Mucosal Immunity,Helmholtz Centre for Infection Research,Braunschweig,Germany;4.Technische Universit?t Dresden, Faculty of Medicine Carl Gustav Carus,Institute for Medical Microbiology and Hygiene, Medical Theoretical Centre,Dresden,Germany |
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| Abstract: | Background Enterohemorrhagic E. coli (EHEC), a subgroup of Shiga toxin (Stx) producing E. coli (STEC), may cause severe enteritis and hemolytic uremic syndrome (HUS) and is transmitted orally via contaminated foods or
from person to person. The infectious dose is known to be very low, which requires most of the bacteria to survive the gastric
acid barrier. Acid resistance therefore is an important mechanism of EHEC virulence. It should also be a relevant characteristic
of E. coli strains used for therapeutic purposes such as the probiotic E. coli Nissle 1917 (EcN). In E. coli and related enteric bacteria it has been extensively demonstrated, that the alternative sigma factor σS, encoded by the rpoS gene, acts as a master regulator mediating resistance to various environmental stress factors. |
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