Binding induced conformational changes of proteins correlate with their intrinsic fluctuations: a case study of antibodies |
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Authors: | Ozlem Keskin |
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Affiliation: | (1) Koc University, Center for Computational Biology and Bioinformatics and College of Engineering, Rumeli Feneri Yolu, 34450 Sariyer, Istanbul, Turkey |
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Abstract: | Background How antibodies recognize and bind to antigens can not be totally explained by rigid shape and electrostatic complimentarity models. Alternatively, pre-existing equilibrium hypothesis states that the native state of an antibody is not defined by a single rigid conformation but instead with an ensemble of similar conformations that co-exist at equilibrium. Antigens bind to one of the preferred conformations making this conformation more abundant shifting the equilibrium. |
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