Dendroaspis natriuretic peptide-like immunoreactivity and its regulation in rat aortic vascular smooth muscle |
| |
Authors: | Woodard Geoffrey E Rosado Juan A Brown John |
| |
Institution: | Department of Physiology, University of Cambridge, Downing Street, CB2 3EG, Cambridge, UK. geoffreyw@intra.niddk.nih.gov |
| |
Abstract: | Dendroaspis natriuretic peptide (DNP) is a recently isolated 38 amino acid peptide that shares structural and functional properties with the other members of the natriuretic peptide family. The present study demonstrates the presence of DNP-like immunoreactivity in sections of rat aorta, carotid artery and renal vasculature and tubules. DNP-like immunoreactivity was detected in culture aortic vascular smooth muscle cells and medium and is regulated by endothelin-1, angiotensin II and sodium nitroprusside but not by transforming growth factor-beta. Our observations indicate that DNP elicits a marked inhibitory effect on DNA synthesis in culture rat aortic vascular smooth muscle cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|