Transposon-tagged mutagenesis in the rat |
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| Authors: | Kitada Kazuhiro Ishishita Satoshi Tosaka Keiko Takahashi Ri-ichi Ueda Masatsugu Keng Vincent W Horie Kyoji Takeda Junji |
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| Institution: | Laboratory of Mammalian Genetics, Division of Genome Dynamics, Creative Research Initiative Sousei, Hokkaido University, North 10 West 8, Kita-ku, Sapporo 060-0810, Japan. kkitada@cast.hokudai.ac.jp |
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| Abstract: | Although the laboratory rat (Rattus norvegicus) is an indispensable experimental animal for biomedical research and drug development, the lack of embryonic stem cell lines hampers gene-knockout studies. Here we report the successful generation of insertional mutant rats using the Sleeping Beauty (SB) transposon system. This would benefit a variety of biomedical research fields for which the rat model is better suited than the mouse model. |
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