Pharmacologic actions of capsaicin: apparent involvement of substance P and serotonin. |
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| Authors: | R M Virus G F Gebhart |
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| Affiliation: | Department of Pharmacology University of Iowa Iowa City, Iowa 52242, USA |
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| Abstract: | The pharmacologic actions of capsaicin in the cardiovascular, respiratory, sensory, thermoregulatory, and gastrointestinal systems were reviewed as were the ultrastructural, neurophysiological, and neurochemical effects produced by this drug. Present evidence strongly suggests that substance P and serotonin are both involved in the pharmacological activity of capsaicin. Capsaicin apparently produces no direct effects on GABA-ergic, enkephalinergic or catecholaminergic systems. |
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