Survivin mRNA antagonists using locked nucleic acid, potential for molecular cancer therapy |
| |
Authors: | Fisker Niels Westergaard Majken Hansen Henrik Frydenlund Hansen Jens Bo |
| |
Institution: | Santaris Pharma A/S, Boege Allé 3, DK-2970 Hoersholm, Denmark. NFN@santaris.com |
| |
Abstract: | We have investigated the effects of different locked nucleic acid modified antisense mRNA antagonists against Survivin in a prostate cancer model. These mRNA antagonists were found to be potent inhibitors of Survivin expression at low nanomolar concentrations. Additionally there was a pronounced synergistic effect when combining the mRNA antagonists against Survivin with the chemotherapeutic Taxol. This effect was demonstrated at concentrations of antagonists far lower than any previously demonstrated, indicating the high potential of locked nucleic acid for therapeutic use. Further characterisations in vivo are ongoing. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|