Calcium and calcium-binding proteins in the nucleus |
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| Authors: | James S C Gilchrist Michael P Czubryt Grant N Pierce |
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| Institution: | (1) Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, 351 Tache Avenue, R2H 2A6 Winnipeg, Manitoba, Canada;(2) Department of Physiology, University of Manitoba, R2H 2A6 Winnipeg, Manitoba, Canada;(3) Present address: Department of Oral Biology, Faculty of Dentistry, University of Manitoba, 780 Bannatyne Avenue, R3E 0W2 Winnipeg, Manitoba, Canada |
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| Abstract: | Calcium has long been known to play a role as a key cytoplasmic second messenger, but until relatively recently its possible involvement in nuclear signal transduction and the regulation of nuclear events has not been extensively studied. Evidence revealing the presence of transmembrane nuclear Ca2+ gradients and a variety of intranuclear Ca2+ binding proteins has fueled renewed interest in this key ion and its involvement in cell-cycle timing and division, gene expression, and protein activation. This review will offer an overview of the current state of knowledge and theory regarding calcium orchestration of nuclear functions and events and discuss possible future directions in this field of study. |
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| Keywords: | calcium nucleus calpain calmodulin cell division gene expression |
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