Neurotrophin action on a rapid timescale |
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Authors: | Kovalchuk Yury Holthoff Knut Konnerth Arthur |
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Affiliation: | Institut für Physiologie, Ludwig-Maximilians-Universit?t München, 80336 München, Germany. |
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Abstract: | Mechanisms underlying the fast action of neurotrophins include intracellular Ca(2+) signaling, neuronal excitation, augmentation of synaptic excitation by modulation of N-methyl-d-aspartate receptor activity and control of synaptic inhibition through the regulation of the K(+)-Cl(-) cotransporter KCC2. The fastest action of brain-derived neurotrophic factor and neurotrophin-4/5 occurs within milliseconds, and involves activation of TrkB and the opening of the Na(+) channel Na(v)1.9. Through these rapid actions, neurotrophins shape neuronal activity, modulate synaptic transmission and produce instructive signals for the induction of long-term changes in the efficacy of synaptic transmission. |
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