Towards a matrix mechanics framework for dynamic protein network |
| |
Authors: | Sanjoy K Bhattacharya |
| |
Institution: | (1) Bascom Palmer Eye Institute, University of Miami, 1638 NW 10th Avenue, Suite 706A, Miami, FL 33136, USA |
| |
Abstract: | Protein–protein interaction networks are currently visualized by software generated interaction webs based upon static experimental
data. Current state is limited to static, mostly non-compartmental network and non time resolved protein interactions. A satisfactory
mathematical foundation for particle interactions within a viscous liquid state (situation within the cytoplasm) does not
exist nor do current computer programs enable building dynamic interaction networks for time resolved interactions. Building
mathematical foundation for intracellular protein interactions can be achieved in two increments (a) trigger and capture the
dynamic molecular changes for a select subset of proteins using several model systems and high throughput time resolved proteomics
and, (b) use this information to build the mathematical foundation and computational algorithm for a compartmentalized and
dynamic protein interaction network. Such a foundation is expected to provide benefit in at least two spheres: (a) understanding
physiology enabling explanation of phenomenon such as incomplete penetrance in genetic disorders and (b) enabling several
fold increase in biopharmaceutical production using impure starting materials. |
| |
Keywords: | Protein–protein interaction Dynamic network Channeling Matrix mechanics Mathematical foundation Time-resolved proteomics |
本文献已被 SpringerLink 等数据库收录! |
|