Role of nitric oxide on purinergic signalling in the cochlea |
| |
Authors: | Narinobu Harada |
| |
Institution: | (1) Harada Ear Institute, Tomoi 2-34-27, Higashiosaka, Osaka 577-0816, Japan |
| |
Abstract: | In the inner ear, there is considerable evidence that extracellular adenosine 5′-triphosphate (ATP) plays an important role
in auditory neurotransmission as a neurotransmitter or a neuromodulator, although the potential role of adenosine signalling
in the modulation of auditory neurotransmission has also been reported. The activation of ligand-gated ionotropic P2X receptors
and G protein-coupled metabotropic P2Y receptors has been reported to induce an increase of intracellular Ca2+ concentration (Ca2+]i) in inner hair cells (IHCs), outer hair cells (OHCs), spiral ganglion neurons (SGNs), and supporting cells in the cochlea.
ATP may participate in auditory neurotransmission by modulating Ca2+]i in the cochlear cells. Recent studies showed that extracellular ATP induced nitric oxide (NO) production in IHCs, OHCs, and
SGNs, which affects the ATP-induced Ca2+ response via the NO-cGMP-PKG pathway in those cells by a feedback mechanism. A cross-talk between NO and ATP may therefore
exist in the auditory signal transduction. In the present article, I review the role of NO on the ATP-induced Ca2+ signalling in IHCs and OHCs. I also consider the possible role of NO in the ATP-induced Ca2+ signalling in SGNs and supporting cells. |
| |
Keywords: | Cochlea Nitric oxide P2 receptors Feedback |
本文献已被 SpringerLink 等数据库收录! |
|