Outer membrane protein a of Salmonella enterica serovar Typhimurium activates dendritic cells and enhances Th1 polarization |
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| Authors: | Jun Sik Lee In Duk Jung Chang-Min Lee Jin Wook Park Sung Hak Chun Soo Kyung Jeong Tae kwun Ha Yong Kyoo Shin Dae Jin Kim Yeong-Min Park |
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| Affiliation: | 1.Department of Microbiology and Immunology,Albert Einstein College of Medicine,Bronx,USA;2.Department of Microbiology and Immunology & National Research Laboratory of Dendritic Cell Differentiation & Regulation,Pusan National University School of Medicine,Yang-san,South Korea;3.Department of Surgery,Busan Paik Hospital, Inje University, College of Medicine,Busan,South Korea;4.College of Medicine,Chung-Ang University,Dongjak-Gu,Korea;5.Department of Anatomy, College of Medicine,Chung-Ang University,Dongjak-Gu,Korea |
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| Abstract: | Background Typhoid, which is caused by Salmonella enterica serovar Typhimurium, remains a major health concern worldwide. Multidrug-resistant strains of Salmonella have emerged which exhibit increased survivability and virulence, thus leading to increased morbidity. However, little is known about the protective immune response against this microorganism. The outer membrane protein (Omp)A of bacteria plays an important role in pathogenesis. |
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