The biological activity of atrial natriuretic factor cleaved by endoprotease 3.4.24.11. |
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| Authors: | R D Ghai R L Webb J L Sonnenberg Y Sakane G Ghai |
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| Affiliation: | Research Department, CIBA-GEIGY Corporation, Summit, New Jersey 07901. |
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| Abstract: | Ring cleavage of atrial natriuretic peptide (ANF) between Cys7 and Phe8 by endoprotease 3.4.24.11 yields X-ANF. Since endoprotease 3.4.24.11 may contribute to ANF metabolism in vivo, the present study determined if X-ANF exhibits reduced biological activity in comparison to the parent molecule. |
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