Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors |
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Authors: | Pullagurla Manik R Westkaemper Richard B Glennon Richard A |
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Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond 23298-0540, USA. |
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Abstract: | A graphics model of the human 5-HT6 receptor was constructed and automated docking studies were performed. The model suggests that 5-HT6 antagonist arylsulfonyltryptamines might bind differently than that of the agonist serotonin. Furthermore, the model explains many of the empirical results from our previous structure-affinity studies. |
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