Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors |
| |
| Authors: | Pullagurla Manik R Westkaemper Richard B Glennon Richard A |
| |
| Institution: | Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond 23298-0540, USA. |
| |
| Abstract: | A graphics model of the human 5-HT6 receptor was constructed and automated docking studies were performed. The model suggests that 5-HT6 antagonist arylsulfonyltryptamines might bind differently than that of the agonist serotonin. Furthermore, the model explains many of the empirical results from our previous structure-affinity studies. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
