Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure-anti-mycobacterial activities |
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| Authors: | Macaev Fliur Rusu Ghenadie Pogrebnoi Serghei Gudima Alexandru Stingaci Eugenia Vlad Ludmila Shvets Nathaly Kandemirli Fatma Dimoglo Anatholy Reynolds Robert |
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| Institution: | Institute of Chemistry, Academy of Sciences of Moldova, Chisinau, MD-2028, Republic of Moldova. flmacaev@cc.acad.md |
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| Abstract: | The preparation of novel 5-aryl-2-thio-1,3,4-oxadiazoles 4a-41 and the computer-aided study of their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) are reported. The average accuracy of the electronic-topological method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%. |
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