A new method of preparation of pyocyanin and demonstration of an unusual bacterial sensitivity. |
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| Authors: | M Knight P E Hartman Z Hartman V M Young |
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| Affiliation: | 1. Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218 USA;2. Baltimore Cancer Research Center, DCT, NCI, University of Maryland Hospital, Baltimore, Maryland 21201 USA |
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| Abstract: | Pyocyanin was prepared in 60% yield from phenazine methoxysulfate by a photooxidation procedure and purification by silica gel chromatography. Monitoring was performed by thin-layer chromatography. Approximately 50% of clinical Pseudomonas aeruginosa isolates were found to produce pyocyanin at 37°C. Among Proteus strains, P. morganii strains were sensitive to concentrations of pyocyanin 16 to 64 times lower than concentrations that inhibited the growth of P. mirabilis and P. vulgaris strains. |
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| Keywords: | To whom reprint requests should be addressed. |
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