Beyond the Chemiosmotic Theory: Analysis of Key Fundamental Aspects of Energy Coupling in Oxidative Phosphorylation in the Light of a Torsional Mechanism of Energy Transduction and ATP Synthesis—Invited Review Part 1 |
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Authors: | Sunil Nath |
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Institution: | (1) Structural Designs, Sundaram Architects Pvt. Ltd., #19, Kumara Krupa Road, Bangalore, 560 001, India |
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Abstract: | The core of this second article shows how logical errors and inconsistencies in previous theories of energy coupling in oxidative
phosphorylation are overcome by use of a torsional mechanism and the unified theory of ATP synthesis/hydrolysis. The torsional
mechanism is shown to satisfy the pioneering and verified features of previous mechanisms. A considerable amount of data is
identified that is incompatible with older theories but is now explained in a logically consistent and unified way. Key deficiencies
in older theories are pinpointed and their resolution elucidated. Finally, major differences between old and new approaches
are tabulated. The new theory now provides the elusive details of energy coupling and transduction, and allows several novel
and experimentally verifiable predictions to be made and a considerable number of applications in nanotechnology, energy conversion,
systems biology, and in health and disease are foreseen. |
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