A new member of the troponin C superfamily: Comparison of the primary structures of rat oncomodulin and rat parvalbumin |
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Authors: | J. P. MacManus D. C. Watson M. Yaguchi |
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Affiliation: | 1. Division of Biological Sciences, National Research Council of Canada, K1A OR6, Ottawa, Canada
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Abstract: | When the amino-acid sequence of the 108-residue, rat tumour calcium-binding protein, oncomodulin, was aligned with that of rat muscle parvalbumin, 55 homologous positions were found, with an additional 33 single base-pair substitutions. This extensive homology, with virtual identity of the calcium-binding domains, signalled oncomodulin to be a member of the troponin C superfamily. The presence of Cys-18 and Phe-66 in oncomodulin, plus its isoelectric point of 3.9, suggest that this tumour protein is a beta-parvalbumin, rather than a muscle alpha-parvalbumin. |
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