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Identification and characterization of antifungal active substances of Streptomyces hygroscopicus BS-112 |
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| Authors: | Nan Zhang Zhen Song Yuhua Xie Ping Cui Hongxia Jiang Tao Yang Ruicheng Ju Yuhua Zhao Jinyu Li Xunli Liu |
| Institution: | 1. College of Life Sciences, Neijiang Normal University, Neijiang, 641112, People’s Republic of China 2. College of Forestry, Shandong Agricultural University, Daizong Street, Taishan District, Tai’an, 271018, People’s Republic of China 3. Key Laboratory of Regional Characteristic Agricultural Resources, Department of Education, Neijiang, 641112, People’s Republic of China 4. Department of Chemistry and Life Science, Hechi University, Yizhou, 546300, People’s Republic of China |
| Abstract: | An antifungal Actinomyces BS-112 strain, with Aspergillus flavus as the target pathogen, was isolated from soil in the forest land of Mountain Tai. This strain showed a strong antagonistic activity against various mold fungi in food and feed. Strain BS-112 was identified as Streptomyces hygroscopicus based on its morphologic, cultural, physiological, biochemical characteristics, cell wall components and 16S rDNA sequence. Four active components were separated and purified from strain BS-112. These four antifungal components were identified as tetrins A and B and tetramycins A and B using spectroscopic analysis including mass spectrometry and nuclear magnetic resonance spectroscopy. Tetrins A and B and tetramycins A and B strongly inhibited the growth of A. flavus, A. alutaceus, A. niger, and A. fumigatus in vitro. |
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