In vitro secretion profiles of interleukin (IL)-1beta, IL-6, IL-8, IL-10, and TNF alpha after selective infection with Escherichia coli in human fetal membranes |
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Authors: | Veronica Zaga-Clavellina Guadalupe Garcia-Lopez Hector Flores-Herrera Aurora Espejel-Nuñez Arturo Flores-Pliego Diana Soriano-Becerril Rolando Maida-Claros Horacio Merchant-Larios Felipe Vadillo-Ortega |
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Affiliation: | 1. Biomedical Research Branch, Instituto Nacional de Perinatologia "Isidro Espinosa de los Reyes", México City, México 2. Direction of Research, Instituto Nacional de Perinatologia "Isidro Espinosa de los Reyes", México City, México 3. Microbiology and Parasitology, Instituto Nacional de Perinatologia "Isidro Espinosa de los Reyes", México City, México 4. Neonatology Branch, Instituto Nacional de Perinatologia "Isidro Espinosa de los Reyes", México City, México 5. Biomedical Research Institute, Universidad Nacional Autónoma de México, México City, México
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Abstract: | Background Chorioamniotic membranes infection is a pathologic condition in which an abnormal secretion of proinflammatory cytokines halts fetal immune tolerance. The aim of the present study was to evaluate the functional response of human chorioamniotic membranes, as well as the individual contribution of the amnion and choriodecidua after stimulation with Escherichia coli, a pathogen associated with preterm labor. |
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