An environmental signature for 323 microbial genomes based on codon adaptation indices |
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Authors: | Hanni Willenbrock Carsten Friis Agnieszka S Juncker and David W Ussery |
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Institution: | (1) Center for Biological Sequence Analysis, BioCentrum-DTU, The Technical University of Denmark, DK-2800 Lyngby, Denmark |
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Abstract: | Background Codon adaptation indices (CAIs) represent an evolutionary strategy to modulate gene expression and have widely been used to
predict potentially highly expressed genes within microbial genomes. Here, we evaluate and compare two very different methods
for estimating CAI values, one corresponding to translational codon usage bias and the second obtained mathematically by searching
for the most dominant codon bias. |
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