Clusters of orthologous genes for 41 archaeal genomes and implications for evolutionary genomics of archaea |
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Authors: | Kira S Makarova Alexander V Sorokin Pavel S Novichkov Yuri I Wolf Eugene V Koonin |
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Institution: | (1) National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA |
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Abstract: | Background An evolutionary classification of genes from sequenced genomes that distinguishes between orthologs and paralogs is indispensable
for genome annotation and evolutionary reconstruction. Shortly after multiple genome sequences of bacteria, archaea, and unicellular
eukaryotes became available, an attempt on such a classification was implemented in Clusters of Orthologous Groups of proteins
(COGs). Rapid accumulation of genome sequences creates opportunities for refining COGs but also represents a challenge because
of error amplification. One of the practical strategies involves construction of refined COGs for phylogenetically compact
subsets of genomes. |
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Keywords: | |
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