Evolution of two distinct phylogenetic lineages of the emerging human pathogen <Emphasis Type="Italic">Mycobacterium ulcerans</Emphasis> |
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Authors: | Michael Käser Simona Rondini Martin Naegeli Tim Stinear Francoise Portaels Ulrich Certa Gerd Pluschke |
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Institution: | (1) Swiss Tropical Institute, Socinstr. 57, 4002 Basel, Switzerland;(2) Department of Microbiology, Monash University, Wellington Rd, Clayton, 3800, Australia;(3) Institute of Tropical Medicine, Antwerp, 2000, Belgium;(4) F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland |
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Abstract: | Background Comparative genomics has greatly improved our understanding of the evolution of pathogenic mycobacteria such as Mycobacterium tuberculosis. Here we have used data from a genome microarray analysis to explore insertion-deletion (InDel) polymorphism among a diverse
strain collection of Mycobacterium ulcerans, the causative agent of the devastating skin disease, Buruli ulcer. Detailed analysis of large sequence polymorphisms in
twelve regions of difference (RDs), comprising irreversible genetic markers, enabled us to refine the phylogenetic succession
within M. ulcerans, to define features of a hypothetical M. ulcerans most recent common ancestor and to confirm its origin from Mycobacterium marinum. |
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