Contraction of guinea pig gail bladder strips by leukotrienes and other agonists |
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Authors: | P Yusko RA Hall AW Ford-Hutchinson |
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Institution: | Merck Frosst Canada Inc., P.O. Box 1005 Pointe Claire - Dorval, Quebec, Canada, H9R 4P8 |
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Abstract: | In the presence of indomethacin, Leukotriene C4 (LTC4), LTD4 and LTE4 were shown to be contractile agents
on guinea pig gall bladder strips. The respective pD2 values for LTC4, LTD4 ad LTE4 were 9.1, 9.1 and 7.7. The contractile effects of LTD4 were not mediated through the generation of cyclooxygenase products and were antagonized by the SRS-A antagonist FPL-55712. The effects of PGE1, PGF2α, the endoperoxide analogue U44069 and histamine on gall bladder strips were also examined. All these agents caused dose-related contractions but were considerably less potent than the leukotrienes. Leukotrienes are therefore potent contractile agents on the guinea pig gall bladder and may contribute to gall bladder contractions or spasms
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Keywords: | correspondence |
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