Variations in the response of five strains of mice to Leishmania mexicana. |
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| Authors: | H Pérez F Labrador J W Torrealba |
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| Affiliation: | 1. Instituto Venezolano de Investigaciones Científicas, Centre de Microbiología Celular, Adpo. 1827, Caracas, Venezuela;2. Instituto Venezolano de Investigaciones Científicas, Centre de Microbiología Celular, Adpo. 1827, Caracas, Venezuela;3. Universidad de Carabobo, Estado Carabobo, Venezuela |
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| Abstract: | Five strains of mice were studied in their ability to support Leishmania mexicana infection. Four strains, AKR, C57BL/6, DBA/2 and NMRI, were relatively resistant to cutaneous leishmaniasis. These strains developed delayed type hypersensitivity responses to leishmanial antigens and produced agglutinating antibodies. On the other hand Balb/c mice, highly susceptible to infection, failed to develop delayed type hypersensitivity responses and showed an impaired production of antibodies. Hybrids produced by mating C57BL/6 males and Balb/c females were no more susceptible than C57BL/6 mice, suggesting that resistance is inherited as a dominant character. |
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| Keywords: | AKR C57BL/6 DBA/2 NMRI Balb/c hybrid delayed type hypersensitivity response agglutinating antibodies |
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