Photosensitized splitting of pyrimidine dimers by indole derivatives |
| |
| Authors: | C Helene M Charlier |
| |
| Affiliation: | 1. Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg, South Africa;2. Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa;3. SAMRC Herbal Drugs Research Unit, Faculty of Science, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa;4. Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands;5. Department of Chemistry, University of Pretoria, Private Bag X20, Hatfield 0028, Pretoria, South Africa |
| |
| Abstract: | Excitation of tryptophan and 5-hydroxytryptophan at wavelengths longer than 290 and 310 nm, respectively, in the presence of pyrimidine dimers leads to a sensitized splitting of these dimers. The reaction is more efficient in frozen than in fluid aqueous solutions. The fluorescence of tryptophan and 5-hydroxytryptophan is quenched by thymine dimers. These results suggest that splitting occurs as a result of electron transfer from the excited indole derivative to the pyrimidine dimer. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
