Immunoglobulin transport across polarized epithelial cells |
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Authors: | Rojas Raul Apodaca Gerard |
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Affiliation: | Laboratory of Epithelial Cell Biology, Renal Electrolyte Division of the Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. |
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Abstract: | IgA, IgG and IgM are transported across epithelial cells in a receptor-mediated process known as transcytosis. In addition to neutralizing pathogens in the lumen of the gastrointestinal, respiratory and urogenital tracts, these antibody-receptor complexes are now known to mediate intracellular neutralization of pathogens and might also be important in immune activation and tolerance. Recent studies on the intracellular transport pathways of antibody-receptor complexes and antibody-stimulated receptor-mediated transcytosis are providing new insight into the nature and regulation of endocytic pathways. |
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