A blast from the past: clearance of apoptotic cells regulates immune responses |
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| Authors: | Savill John Dransfield Ian Gregory Chris Haslett Chris |
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| Affiliation: | MRC/University of Edinburgh Centre for Inflammation Research, Department of Clinical & Surgical Sciences (Internal Medicine), Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK. J.Savill@ed.ac.uk |
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| Abstract: | Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation. Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future. |
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