Bioreversible phosphate protective groups: Synthesis and stability of model acyloxymethyl phosphates |
| |
| Authors: | Devendra N. Srivastva David Farquhar |
| |
| Affiliation: | Department of Developmental Therapeutics, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, 6723 Bertner Avenue, Houston, Texas 77030 USA |
| |
| Abstract: | Six bis(acyloxymethyl) esters of phenyl phosphate and benzyl phosphate and three acyloxymethylbenzylphenyl phosphates were prepared. Debenzylation of benzyl analogs gave respective free acids which were isolated as cyclohexylammonium salts. Stability of bis(acyloxymethyl)phenyl phosphates were studied in various aqueous buffers, hog liver esterase, and mice plasma. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
