Production of recombinant endostatin in milk from transgenic mice |
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| Authors: | Zavadskaia E S Zakharova E S Kadulin S G Kibardin A V Kiselev S L Gnuchev N V |
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| Institution: | Institute of Gene Biology, Russian Academy of Sciences, Moscow, 117334 Russia. |
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| Abstract: | Using the bovine alpha S1-casein gene, a genetic construct with an endostatin-coding fragment of the mouse collagen XVIII cDNA was designed to express endostatin in milk of transgenic animals. Several transgenic mice were obtained. The mice secreted endostatin in milk at 70-300 ng/microliter and transmitted this character to their progeny. |
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