Reaction of dipeptidylpeptidase IV with substrate-analogous azapeptides. |
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| Authors: | U Neumann T Steinmetzer A Barth H U Demuth |
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| Institution: | Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR. |
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| Abstract: | The reaction of dipeptidyl peptidase IV (EC 3.4.14.5.) with azapeptide substrates containing azaalanine or azaproline in the P1-position was investigated. Accumulation of a fairly stable acyl-enzyme could be shown for ester substrates. Ala-AzaPro-pNA is a very poor substrate of DP IV and does not accumulate an acyl-enzyme. DP IV does not react with active-site titrants for trypsin-like serine proteases. |
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