Up-Regulation of Epithelial Membrane Protein-1 in the Temporal Neocortex of Patients with Intractable Epilepsy |
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Authors: | Yu-qin Li Tao Xue Liang Wang Zu-cai Xu Zhi-qin Xi Jie Yuan Xue-feng Wang Yang-mei Chen Meilin Zhang Lan Yao |
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Institution: | (1) Department of Neurology, The Second Affiliated Hospital, Chongqing Medical University, Lin Jiang Road 76, 400010 Chongqing, China;(2) Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Youyin Road 1, 400016 Chongqing, China |
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Abstract: | Epithelial membrane protein-1 (EMP-1), called Tumor-associated membrane protein, is the marker of a drug-resistant tumor and
take part in the drug-resistant mechanism of tumor, with the relationship of epidermal growth factor receptor (EGFR). Because
there are some similarities between the pathogenesis and the drug resistance mechanism of tumor and the drug resistance mechanisms
in epilepsy. EMP1 expression may be connected with the drug-resistance mechanism of epilepsy. We detected EMP-1 by gene scanning
and immunohistochemistry staining, comparing the IE group and the control group, and we investigated the relationship between
EMP-1 and EGFR by double-label immunofluorescence staining in the IE group. We found expression of EMP-1 mRNA was higher in
IE per the gene scanning, EMP-1 immunoreactivity was apparent in neurons of IE patients but not in the control group, and
the expression of EMP-1 and EGFR occurred in the same neuron. We confirm EMP-1 is abnormally expressed in IE and suggest the
interaction of EGFR and EMP-1 plays a role in the mechanism of drug resistance in epilepsy and may be a new gene for drug
resistance. |
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Keywords: | Intractable epilepsy (IE) Epithelial membrane protein-1 (EMP1) Epidermal growth factor receptor (EGFR) Drug-resistance |
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