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Hybrid Proteins with Short Conformational Epitopes of the Receptor-Binding Domain of SARS-CoV-2 Spike Protein Promote Production of Virus-Neutralizing Antibodies When Used for Immunization |
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| Authors: | Karyagina Anna S. Gromov Alexander V. Grunina Tatyana M. Lyaschuk Alexander M. Poponova Maria S. Kleymenov Denis A. Strukova Natalia V. Generalova Maria S. Ryazanova Anna V. Galushkina Zoya M. Dobrynina Olga Yu. Bolshakova Tatyana N. Sergeeva Maria V. Romanovskaya-Romanko Ekaterina A. Krasilnikov Igor V. Subbotina Marina E. Lunin Vladimir G. |
| Affiliation: | 1.Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098, Moscow, Russia ;2.All-Russia Research Institute of Agricultural Biotechnology, 127550, Moscow, Russia ;3.Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992, Moscow, Russia ;4.Institute of Influenza, Ministry of Health of the Russian Federation, 197376, St. Petersburg, Russia ;5.Saint Petersburg Institute of Vaccines and Sera, FMBA, 198320, St. Petersburg, Russia ; |
| Abstract: | Biochemistry (Moscow) - Based on the previously developed approach, hybrid recombinant proteins containing short conformational epitopes (a.a. 144-153, 337-346, 414-425, 496-507) of the... |
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