Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins |
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Authors: | C C Drinkwater B A Evans R I Richards |
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Affiliation: | Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia. |
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Abstract: | Previously, three proteins have been separately identified as the mouse epidermal growth factor binding protein (EGF-BP). We have identified and sequenced the coding regions of three distinct genes encoding these EGF-BPs from the BALB/c strain. The genes are all members of the glandular kallikrein gene family, which encodes a highly homologous group of serine proteases. Expression of the EGF-BP genes was detected in mouse salivary gland only and was at a relatively similar level for each gene. The isolation of three distinct genes from the one mouse strain indicates that the conflicting data previously reported in the literature are not a result of allelic polymorphisms or strain differences. |
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