LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam |
| |
Authors: | Ouattara Badioré Angenot Luc Guissou Pierre Fondu Pierre Dubois Jacques Frédérich Michel Jansen Olivia van Heugen Jean-Claude Wauters Jean-Noël Tits Monique |
| |
Institution: | Université de Liège, Centre Interfacultaire de Recherche en Pharmacochimie des Substances Naturelles et Synthétiques (CPSNS), Laboratoire de Pharmacognosie, Avenue de l'H?pital 1, B36, B-4000 Liège, Belgium. |
| |
Abstract: | Gradient HPLC coupled to DAD/UV, MS/MS and NMR has been applied to the rapid structure determination of three new isomeric divanilloylquinic acids from Fagara zanthoxyloides collected in Burkina Faso: 3,4-O-divanilloylquinic acid, 3,5-O-divanilloylquinic acid and 4,5-O-divanilloylquinic acid. Furthermore these new compounds named burkinabins A-C could play a useful role in sickle cell disease, as the active agents of Fagara zanthoxylo?des are said to be unidentified aromatic compounds with carboxylic acid grouping (Adesanya, S.A., Sofowora, A., 1983. Biological standardisation of Zanthoxylum roots for antisickling activity. Planta Med. 48, 27-33). |
| |
Keywords: | Fagara zanthoxyloides Rutaceae Divanilloylquinic acids Burkinabins A-C HPLC/MS/NMR Antisickling activity |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|