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HIV takes double hit before entry |
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| Authors: | |
| Institution: | 1.Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center,University of Amsterdam,Amsterdam,The Netherlands;2.Department of Microbiology and Immunology,Weill Medical College of Cornell University,New York,USA |
| Abstract: | In the absence of a vaccine or a cure, identification of novel HIV-1 inhibitors remains important. A paper in Retrovirology describes a rationally designed bi-specific protein that irreversibly damages the viral envelope glycoprotein complex via a two-punch mechanism. In contrast to traditional drugs that inhibit essential steps in the viral life cycle at the cell surface or in the infected cells, this inhibitor cripples free virus in the absence of cells.See research article: http://www.retrovirology.com/content/9/1/104 |
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