Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases |
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| Authors: | Sandro?Dattilo Cesare?Mancuso Guido?Koverech Paola?Di Mauro Maria?Laura?Ontario Cateno?Concetto?Petralia Antonino?Petralia Luigi?Maiolino Agostino?Serra Edward?J?Calabrese Email author" target="_blank">Vittorio?CalabreseEmail author |
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| Institution: | 1.Department of Biomedical and Biotechnological Sciences,University of Catania,Catania,Italy;2.Department of Medical and Surgery Specialties,University of Catania,Catania,Italy;3.Department of Clinical and Experimental Medicine, School of Medicine,University of Catania,Catania,Italy;4.Institute of Pharmacology,Catholic University School of Medicine,Rome,Italy;5.Environmental Health Sciences Division, School of Public Health,University of Massachusetts,Amherst,USA;6.University College London Hospitals,NHS Foundation Trust,London,UK |
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| Abstract: | Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. The possibility of high-throughoutput screening using proteomic techniques, particularly redox proteomics, provide more comprehensive overview of the interaction of proteins, as well as the interplay among processes involved in neuroprotection. Here by introducing the hormetic dose response concept, the mechanistic foundations and applications to the field of neuroprotection, we discuss the emerging role of heat shock protein as prominent member of vitagene network in neuroprotection and redox proteomics as a tool for investigating redox modulation of stress responsive vitagenes. Hormetic mechanisms are reviewed as possibility of targeted therapeutic manipulation in a cell-, tissue- and/or pathway-specific manner at appropriate points in the neurodegenerative disease process. |
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