Differential expression of type-specific c-abl mRNAs in mouse tissues and cell lines. |
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Authors: | M W Renshaw M A Capozza and J Y Wang |
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Institution: | Department of Biology, University of California-San Diego, La Jolla 92093. |
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Abstract: | The mammalian c-abl proto-oncogene produces mRNAs with 5' heterogeneity from two distinct promoters and the alternative splicing of variable 5' exons. By using quantitative RNase protection assays, the relative abundance of two major c-abl mRNAs, type I and type IV, in several mouse tissues and cell lines has been determined. Our results demonstrate that the level of type IV c-abl mRNA is rather constant, whereas that of the type I mRNA varies over a 10-fold range in different tissues and cell types. This finding has interesting implications for the function of the two c-abl proteins. |
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