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Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer |
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| Authors: | Stein Gary S Zaidi Sayyed K Stein Janet L Lian Jane B van Wijnen Andre J Montecino Martin Young Daniel W Javed Amjad Pratap Jitesh Choi Je-Yong Ali Syed A Pande Sandhya Hassan Mohammad Q |
| Affiliation: | Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. gary.stein@umassmed.edu |
| Abstract: | The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment. |
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