The P300 event-related potentials in dementia of the Alzheimer type. Correlations between P300 and monoamine metabolites |
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| Affiliation: | 1. Faculty of Engineering, Mahasarakham University, Kantarawichai, Mahasarakham 44150, Thailand;2. Faculty of Engineering, Rajamangala University of Technology Isan, Khon Kaen Campus, KhonKaen 40000, Thailand;1. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA;2. Laboratory of Clinical Biochemistry and Metabolism, Center of Pediatrics, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg 79106, Germany;1. School of Linguistic Sciences and Arts, Jiangsu Normal University, Xuzhou, 221009, China;2. Collaborative Innovation Center for Language Competence, Xuzhou, 221009, China;3. Jiangsu Key Laboratory of Language and Cognitive Neuroscience, Xuzhou, 221009, China;1. Department of Communicative Disorders, University of Rhode Island, Independence Square I, Kingston, RI 02281, USA;2. Department of Nutrition and Food Sciences, University of Rhode Island, Ranger Hall, Kingston, RI 02881, USA;3. Department of Kinesiology, University of Rhode Island, Independence Square II, Kingston, RI 02881, USA;1. The Key Laboratory of Biomedical Information of Ministry of Education, Institute of Biomedical Engineering, Xi’an Jiaotong University, Xi’an 710049, China;2. Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China;3. Department of Neurology, The First Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an 710061, China |
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| Abstract: | We studied auditory event-related potentials (ERPs) in 40 patients with dementia of the Alzheimer type (DAT). Peak latencies and amplitudes of N100, P200 and P300 components were measured. To study the possible relationships between the ERPs and monoaminergic neurotransmitter functions, CSF neurotransmitter metabolites were also analyzed. In patients with DAT, the P300 amplitude was significantly reduced and the P300 latency was prolonged. CSF concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were decreased. The P300 amplitude was significantly correlated with the 5-HIAA concentration. There were no correlations between the P300 components and the HVA concentration. These findings suggest that the serotonergic system modulates the P300 component of ERPs in patients with DAT. |
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