Bone surface structure in osteopetrotic grey lethal (gl/gl) and microphthalmic (mi/mi) mutant mice as revealed by scanning electron microscopy |
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| Affiliation: | 1. State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, College of Food Engineering and Biotechnology, Tianjin University of Science &Technology, Tianjin 300457, China;2. National R&D Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China;1. Haemophilia Centre/Haemostasis and Thrombosis Unit, Aghia Sophia Children''s Hospital, Athens, Greece;2. Second Radiology Department, “Attikon” University Hospital, Athens, Greece;3. Department of Bone and Mineral Metabolism, Institute of Child Health, Αthens, Greece;4. First Paediatric Department – Athens Medical School, Aghia Sophia Children''s Hospital, Athens- Greece |
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| Abstract: | The surface structure of bone from two genetically distinct osteopetrotic strains of mice, grey lethal (gl) and microphthalmic (mi) has been examined by scanning electron microscopy. Although both conditions produce a classical osteopetrolic phenotype the means by which this is achieved is quite different. gl mice appear to retain woven bone and show no evidence of resorption: mi mice show evidence of imperfect remodelling. These results are in accordance with what is already known of osteoclast structure and function in these mutations. |
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