Treatment of multiple myeloma with nasal spray calcitonin: a histomorphometric and biochemical study |
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| Institution: | 1. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;2. School of Medical Sciences, Örebro University, Örebro, Sweden;3. Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden;4. Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;5. Regional Blood Bank, Sahlgrenska University Hospital, Gothenburg, Sweden;1. College of Physicians and SurgeonsColumbia University Medical CenterNew YorkNYUSA;2. Department of UrologyColumbia University Medical CenterNew YorkNYUSA;3. Division of EndocrinologyDepartment of MedicineColumbia University Medical CenterNew YorkNYUSA;4. Department of UrologyIcahn School of Medicine at Mount SinaiNew YorkNYUSA |
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| Abstract: | To evaluate the effect of calcitonin on the bone lesions of multiple myeloma, we studied 11 patients treated for 3 months with salmon calcitonin in nasal spray (200 IU) and 500 mg of elemental calcium/day. Pre- and post-treatment biochemical and histomorphometric parameters were compared to those of 12 patients treated for the same time with 500 mg elemental calcium alone. Both groups received the same hematological treatment.In the group treated with calcitonin there was a significant increase (P < 0.01) in trabecular bone volume, cortical thickness, osteoid volume and osteoid seam thickness index and the osteoclast resorption surface fell significantly (P < 0.01). There was also a decline (P < 0.001) in corrected serum calcium and OHP/Cr, which accounts for the diminished bone resorption. The group not treated with calcitonin showed only significant changes in OHP/Cr which increase (P < 0.05).Calcitonin was perfectly tolerated by all patients and our results show it to be useful in the treatment of bone lesions of multiple myeloma. |
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