Decreased serum osteocalcin levels in patients with liver cirrhosis |
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| Institution: | 1. Department of Internal Medicine II, University of Vienna, Vienna, Austria;2. Department of Gastroenterology and Hepatology II, University of Vienna, Vienna, Austria;3. Department of Medicine, Hospital Barmherzige Brüder, Vienna, Austria;4. Ludwig Boltzmann Institute for Clinical Endocrinology, Vienna, Austria;5. Ludwig Boltzmann Institute for Gerontology, Vienna, Austria;1. Departamento de Ciencias Químico Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, PRONAF y Estocolmo s/n, 32310, Juárez, Mexico;2. X-ray and Infrared Microspectroscopy Beamline ID21, European Synchrotron Radiation Facility, 71 avenue des Martyrs, 38000, Grenoble, France;1. Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), 8000, Bahía Blanca, Buenos Aires, Argentina;2. Instituto de Ciencias Biológicas y Biomédicas del Sur (INBIOSUR), Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 8000, Bahía Blanca, Buenos Aires, Argentina;1. Division of Applied Oral Science, Nihon University Graduate School of Dentistry, Tokyo, Japan;2. Department of Anatomy, Nihon University School of Dentistry, Tokyo, Japan;3. Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan;4. Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan;5. Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan;1. Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, 27402, USA;2. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, IL, 60612, USA;3. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, OH, 43210, USA;4. Botany Department, Science and Education, The Field Museum of Natural History, Chicago, IL, 60605, USA |
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| Abstract: | Serum levels of osteocalcin (OC) have been found to be a specific biochemical parameter of bone formation. We measured serum levels of osteocalcin, parathyroid hormone (PTH) and 25-hydroxyvitamin D (25(OH)D) in 49 patients with liver cirrhosis, who are known to have an increased prevalence of metabolic bone disease, and a matched control group (n = 35). Serum levels of OC were significantly decreased in the patients with liver cirrhosis when compared to control subjects (P < 0.001). Serum levels of 25(OH)D were decreased (P < 0.001), whereas no statistical difference was found between the serum levels of PTH in the patients with liver cirrhosis and those of the controls. In a subgroup of 23 patients with cirrhosis of the liver and 34 control subjects, the bone mineral content (BMC) of the non-dominant forearm was determined by single photon absorptiometry. BMC was significantly lower in the patient with liver cirrhosis than the control subjects (P < 0.04). Our data demonstrate vitamin D deficiency, decreased bone formation and a decreased BMC in patients with liver cirrhosis. |
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