P300 assessment of early Alzheimer's disease |
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| Institution: | 1. Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy;2. Center for Neurosciences and Neurotechnology, Università di Modena e Reggio Emilia, Italy;3. Neurology Unit, Baggiovara Hospital, AOU Modena, Italy;4. Laboratory Medicine Department, Baggiovara Hospital, AOU Modena, Italy;5. Nuffield Department of Clinical Neurosciences, University of Oxford, UK;1. Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China;2. Department of Psychology, Xinxiang Medical University, Xinxiang, Henan 453003, China;3. Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA;1. Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, South Korea;2. Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea;3. Department of Neurology, Dankook University Hospital, Cheonan, South Korea;4. Department of Neurology, Chungnam National University Sejong Hospital, Sejong, South Korea;5. Department of Neurology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea;6. Department of Neurology, Ajou University School of Medicine, Suwon, South Korea;7. Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, South Korea;8. Department of Neurology, CHA University, Bundang CHA Medical Center, Seongnam, South Korea;9. Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea;1. Department of Electrical Engineering, Indian Institute of Technology Patna, Bihar, India;2. Department of Physiology, All India Institute of Medical Sciences, Patna, Bihar, India;1. Institute of Movement and Neurosciences, German Sport University, Cologne, Germany;2. VasoActive Research Group, School of Health and Sport Sciences, University of the Sunshine Coast, Qld, Australia;3. Sunshine Coast Health Institute, Sunshine Coast Hospital and Health Service, Qld, Australia;4. Institute of Medical Psychology and Behavioral Neurobiology, Eberhard-Karls-Universität Tübingen, 72076, Tuebingen, Germany;5. University of Queensland, School of Movement and Nutrition Sciences, Centre for Research on Exercise, Physical Activity and Health (CRExPAH), Australia;6. Sunshine Coast Mind and Neuroscience – Thompson Institute, University of the Sunshine Coast, Qld, Australia |
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| Abstract: | The P300 (P3) event-related brain potential (ERP) was elicited in 16 demented patients presumed to be in the early stages of Alzheimer's disease and 16 normal control subjects well matched for age, sex, education and occupational level. All subjects performed a simple auditory discrimination task in which a target tone was presented randomly on 20% of the trials. P3 amplitude was smaller and peak latency longer for the Alzheimer patients compared to control subjects. A second ERP task also was administered in which the target tone occurred 50% of the time. Analysis of the target/standard tone presentation sequences indicated that the Alzheimer patient group demonstrated less amplitude difference between the target and standard sequences and longer overall latencies compared to the control group. The results that the P3 ERP component from auditory stimuli can provide useful information about Alzheimer's disease during its early stages. |
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