A comparison of biochemical indices of bone turnover in elderly institutionalized and free-living subjects |
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| Institution: | 1. Rheumatology Department, Cochin Hospital, AP-HP, Paris, France;2. Endocrinology Department, Cochin Hospital, AP-HP, Paris, France;3. Med-Imaps - Plateforme Technologique d''Innovation Biomédicale (PTIB) - Xavier Arnozan Hospital, CHU Bordeaux, Pessac, France;1. Department of Radiology, University of California, San Diego, La Jolla, CA, USA;2. Research and Laboratories Sector, Saudi Food and Drug Authority, Riyadh, Saudi Arabia;3. Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, CA, USA;4. Orthopaedic Research, University of California, San Diego, La Jolla, CA, USA |
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| Abstract: | Plasma concentrations of calcium-phosphate, alkaline phosphatase, 25-hydroxyvitamin D (25(OH)D) and albumin, and fasting urinary sodium/creatinine (Na/Cr), calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (HPr/Cr) were measured in a survey of 208 Chinese elderly subjects living in chronic care institutions, and compared with values from free-living elderly subjects. Plasma parathyroid hormone estimations were also performed on a subpopulation of women living in an institution.Subjects in institutions had higher urinary HPr/Cr ratios in both men and women, as well as higher urinary Ca/Cr ratios in women, suggesting increased bone resorption. These values show significant variation depending on the degree of mobility. Factors which could contribute to the increased bone loss among institutionalized subjects are: reduced physical activity, reduced exposure to sunlight and hence reduced plasma 25(OH)D concentrations, low calcium intake, protein caloric malnutrition and possibly higher sodium intake. Correction of these factors may reduce the risk of fractures among the elderly living in chronic care institutions. |
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