Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing |
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Authors: | Manuel Irimia Jakob Lewin Rukov David Penny Scott William Roy |
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Institution: | 1.Allan Wilson Centre for Molecular Evolution and Ecology,Massey University,Palmerston North,New Zealand;2.Departament de Genètica,Universitat de Barcelona,Barcelona,Spain;3.Department of Molecular Biology,University of Copenhagen,Copenhagen,Denmark |
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Abstract: | Background Alternative splicing has been reported in various eukaryotic groups including plants, apicomplexans, diatoms, amoebae, animals
and fungi. However, whether widespread alternative splicing has evolved independently in the different eukaryotic groups or
was inherited from their last common ancestor, and may therefore predate multicellularity, is still unknown. To better understand
the origin and evolution of alternative splicing and its usage in diverse organisms, we studied alternative splicing in 12
eukaryotic species, comparing rates of alternative splicing across genes of different functional classes, cellular locations,
intron/exon structures and evolutionary origins. |
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