Phenotypic evolution from genetic polymorphisms in a radial network architecture |
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Authors: | Arnaud Le Rouzic Paul B Siegel Örjan Carlborg |
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Affiliation: | (1) Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, Uppsala, SE, 75124, Sweden;(2) Department of Biology, Centre for Ecological and Evolutionary Synthesis, PO 1066, Blindern, 0316, Oslo, Norway;(3) Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0306, USA;(4) Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, Uppsala, SE, 750 07, Sweden |
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Abstract: | Background The genetic architecture of a quantitative trait influences the phenotypic response to natural or artificial selection. One of the main objectives of genetic mapping studies is to identify the genetic factors underlying complex traits and understand how they contribute to phenotypic expression. Presently, we are good at identifying and locating individual loci with large effects, but there is a void in describing more complex genetic architectures. Although large networks of connected genes have been reported, there is an almost complete lack of information on how polymorphisms in these networks contribute to phenotypic variation and change. To date, most of our understanding comes from theoretical, model-based studies, and it remains difficult to assess how realistic their conclusions are as they lack empirical support. |
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