Antibiotic as ligand. Coordinating behavior of the cephalexin towards Zn(II) and Cd(II) ions |
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| Authors: | M J Lozano J Borrás |
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| Affiliation: | 1. Departamento de Química Inorgánica, Facultad de Farmacia, E. García-España. Spain;2. Departamento de Química Inorgánica, Facultad de Quimicas, Universidad de Valencia, Spain;1. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156/83111, Iran;2. Research Institute for Fundamental Sciences (RIFS), University of Tabriz, Tabriz, Iran;3. Faculty of Arts and Sciences, Department of Physics, Ondokuz, Mayıs University, 55139, Samsun, Turkey;4. Department of Medical Biotechnology, Nanotechnology Research Center, Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;5. Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Chemical Engineering, Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, PR China;2. Department of Chemistry, University of Nottingham Malaysia Campus, Semenyih, Selangor 43500, Malaysia;1. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan;2. International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Tsukuba, Japan;3. Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Japan;1. Department of Chemistry, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia;2. École Normale Supérieure-PSL Research University, Département de Chimie, Sorbonne Universités – UPMC Univ Paris 06, CNRS UMR 7203 LBM, 24, rue Lhomond, 75005, Paris, France;3. UMR-MD1, Aix-Marseille Université, IRBA, Faculté de Médecine, 27 boulevard Jean Moulin, 13385, Marseille, France;4. Research Centre for Crystalline Materials, Faculty of Science and Technology, Sunway University, No. 5 Jalan Universiti, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia;5. Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, Université Paris-Sud, Bât 532 CEA, Saclay, 91191, Gif sur Yvette cedex, France;6. Institut de Chimie Moléculaire et des Matériaux d''Orsay, Bât. 420 Université Paris-Sud, 91405, Orsay, France;7. Department of Obstetrics and Gynaecology, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia;8. UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia;9. Department of Chemistry, Cape Breton University, Sydney, Nova Scotia, B1P 6L2, Canada |
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| Abstract: | The complex formation equilibria of Zn(II) and Cd(II) with cephalexin have been studied through potentiometric titrations. Experimental data were analyzed using the least squares computer program SUPERQUAD. The stability constants were 1g beta ZnCEX+ = 2.40, 1g beta Zn(CEX)(OH) = -4.54, 1g beta CdCEX+ = 2.18, and 1g beta Cd(CEX)(OH) = -5.18 (I = 0.1 M NaNO3), CEX complexes of formulae Zn(CEX)2(3)H2O and Cd(CEX)(OH)H2O have been synthesized and characterized by elemental analysis, IR spectra, conductivity measurements, and electronic and NMR spectra. The thermal behavior of the synthesized compounds were studied by TGA and DTA. We conclude that the metal ion interacts with the amido group of CEX. |
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