Effect of cell lipid composition on the formation of nonspecific antibiotic resistance in alkanotrophic rhodococci |
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Authors: | M S Kuyukina I B Ivshina M I Rychkova O B Chumakov |
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Institution: | (1) Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, ul. Lenina 11, 614600 Perm, Russia |
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Abstract: | The antibiotic resistance and lipid composition of rhodococci grown in rich organic media with gaseous or liquidn-alkanes were studied. Hydrocarbon-grown rhodococci exhibited an increased resistance to a wide range of antibiotics (aminoglycosides,
linkosamides, macrolides, β-lactams, and aromatic compounds). The enhanced antibiotic resistance of rhodococci grown onn-alkanes correlated with an increased content of total cell lipids (up to 14–28%) and saturated straight-chain fatty acids
(C16:0, C18:0, C21:0) and was accompanied by the appearance of cardiolipin and phosphatidylglycerol in cells. These lipid compounds are supposed
to promote the formation of nonspecific antibiotic resistance in rhodococci by decreasing the permeability of their cell envelope
to antibiotics. |
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Keywords: | Rhodococcus n-alkanes antibiotic resistance total cell lipids phospholipids fatty acid composition |
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