Vitamin E deficiency has a pathological role in myocytolysis in cardiomyopathic Syrian hamster (BIO14.6) |
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Authors: | T Sakanashi S Sako A Nozuhara K Adachi T Okamoto Y Koga H Toshima |
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Institution: | 3rd Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan. |
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Abstract: | This study revealed the occurrence of vitamin E deficiency in the myocardium of 60-day-old Syrian cardiomyopathic hamsters (BIO14.6), and that this deficiency might be related to the increase in lipid peroxide. Vitamin E administration for ten days effectively restored creatininekinase activity and decreased the lipid peroxide content in the myocardium, returning these to normal control levels (F1b). These results indicate that vitamin E deficiency, possibly combined with oxidative stress in the early cardiomyopathic stage plays an important role in initiating the pathogenesis of myocardial lesions. |
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